Back when diclofenac + dmso was rx-only and crazy expensive I tried making my own formulation with ibuprofen and dmso for back pain hoping it wouldn’t tweak out my stomach. According to what I read, ibuprofen would be very well absorbed with dmso.

After applying the ointment I got an upset stomach in minutes so yeah…. It was well absorbed.

https://pmc.ncbi.nlm.nih.gov/articles/PMC3141840/

https://my.clevelandclinic.org/health/drugs/21230-diclofenac...